homeostasis – Communicable Diseases Research

COVID-19: imbalanced cell-mediated immune response drives to immunopathology

Article

Published on 2022-12-012022-11-15
Journal: Emerging Microbes & Infections
[Category] COVID19(2023년), SARS, 치료제,

Early suppression of antiviral host response and protocadherins by SARS-CoV-2 Spike protein in THP-1-derived macrophage-like cells

Article

Published on 2022-10-202022-11-15
Journal: Frontiers in Immunology
[Category] COVID19(2023년), SARS, 치료제,

Central and effector memory T cells in peripheral blood of patients with interstitial pneumonia: preliminary clues from a COVID-19 study

Article

Published on 2022-10-102022-11-15
Journal: Respiratory Research
[Category] COVID19(2023년), SARS, 바이오마커,

[키워드] acute phase addition affected Analysis biological marker CD3+ cells CD4 CD8 Cell cell population central memory Central memory T cells control group control patient controls COVID-19 COVID-19 diagnosis cross-sectional decrease described differential expression disease early phase effector effector memory Effector memory T cells flow cytometry group homeostasis hospital Hospital admission immune increase interstitial interstitial lung involvement interstitial pneumonia lymphocyte subpopulation Lymphocyte subpopulations memory memory T memory T cells Patient patients with pneumonia performed Peripheral blood peripheral lymphocyte Pneumonia positive pre-existing T-cell protocol reactivity recruited Research Respiratory disease SARS-CoV-2 SARS-CoV-2 PCR SARS-CoV-2. severe COVID-19 patients significant decrease significant increase study participant study period subpopulations subset T cell T-cell therapeutic viral respiratory infections were assessed
[DOI] 10.1186/s12931-022-02190-8 PMC 바로가기

Live and let die: signaling AKTivation and UPRegulation dynamics in SARS-CoVs infection and cancer

Article

Published on 2022-10-032022-11-16
Journal: Cell Death & Disease
[Category] COVID19(2023년), SARS, 신약개발, 유전자 메커니즘,

Inhaled aviptadil for the possible treatment of COVID-19 in patients at high risk for ARDS: study protocol for a randomized, placebo-controlled, and multicenter trial

Article

Published on 2022-09-202022-11-16
Journal: Trials
[Category] SARS, 변종,

[키워드] acute lung injury acute respiratory distress addition adverse effects antibody applied ARDS Aviptadil baseline Clinical improvement clinical status Concentration conducted COVID-19 COVID-19 in patient COVID-19 patient defined double-blinded Efficacy and safety Europe exclusion criteria FIVE hemodynamic instability high risk homeostasis hospital discharge Hospitalization immunomodulating IMPROVE indicate Inhaled intensive care intestinal intravenously lung lung tissue management mechanical ventilation metabolism Mortality multicenter Multicenter trial pandemic Pathways Patient patients hospitalized peptide placebo-controlled Prevent primary endpoint pro-inflammatory Prognosis Protein Public Hospital Randomized randomized trial Randomly reduction Regulation respiratory complication Risk factors SARS-CoV-2 severe disease course shown standard care stratified Study protocol suggested syndrome the SARS-CoV-2 therapeutic agent Therapies therapy Treatment unique vaccination Vaccine variants of SARS-CoV-2 Vasoactive VIP VIP. with COVID-19 World Health Organization
[DOI] 10.1186/s13063-022-06723-w PMC 바로가기

The choroid plexus and its role in the pathogenesis of neurological infections

Article

Published on 2022-09-102022-11-15
Journal: Fluids and Barriers of the CNS
[Category] SARS, 치료기술, 치료제,

[키워드] Activation Alter bidirectional Blood–CSF barrier Borrelia Borrelia burgdorferi Brain Cell cells cellular response Central nervous system cerebrospinal fluid changes in chemotaxis choroid Choroid plexus circulating CNS CNS disorder cytokine dendritic cells develop Diseases disorder driving epithelia epithelial epithelial cell function greater highlight homeostasis homing hydrocephalus Immune cell immune cells immune response Immunity immunological Including induce Infection infections Inflammation inflammatory signal John Cunningham virus junction knowledge less macrophages Neuroinflammation neurological pathogen Pathogenesis Pathogens pharmacological intervention promote provide Research SARS-CoV-2 shown T cells target these cell virus ZIKA virus.
[DOI] 10.1186/s12987-022-00372-6 PMC 바로가기

Lipocalin-2 is an essential component of the innate immune response to Acinetobacter baumannii infection

Article

Published on 2022-09-022022-11-16
Journal: PLoS Pathogens
[Category] 유전자 메커니즘,

[키워드] Acinetobacter acquisition antimicrobial drug Bacteremia Bacterial bloodstream infection caused change characteristic COVID-19 pandemic Critical curtail dissemination essential nutrient evaluated exhibited expand expression expression pattern feasible gene encoding Gene Expression Gram-negative bacteremia growth Health healthcare homeostasis Host host gene expression Immunity impairment include induce Infection inhibit inhibiting innate immune response involved lack Lcn2 lipocalin-2 MDR mechanism mice Mortality multidrug resistant multifactorial organ organ-specific pathogen Pneumonia Prevalence proliferation Protective Protein required reveal robust S100A8 S100A9 secondary bacterial pneumonia sequestering survival target therapeutic tissues Transcription transcriptional Treatment upregulated ventilated patient Ventilator-associated pneumonia were infected World Health Organization
[DOI] 10.1371/journal.ppat.1010809 PMC 바로가기

COVID-19 induced Diabetes: A novel presentation

Review article

Published on 2022-09-012022-10-05
Journal: Diabetes research and clinical practice
[Category] SARS, 유전자 메커니즘, 진단, 치료기술,

[키워드] affected assumed Atypical Beta cells biochemical biochemical pathway Case series cause caused Cell cell damage Complication COVID COVID-19 COVID-19 pandemic COVID-19 patient critically ill patients Cross-sectional studies detect diabete diabetes Diabetes Mellitus Diagnosis Diagnostic Criteria dysregulation Follow-up Glucose Google Scholar homeostasis implication include Infection insulin resistance management mechanisms meta-analyses Mortality mortality rate outcome parameter Pathogenesis pathophysiological mechanism Patient Prognosis Result risk factor SARS-CoV-2 significantly higher trajectory type 2 diabetes was performed
[DOI] 10.1016/j.diabres.2022.110034 [Article Type] Review article

Dysregulated miRNAs network in the critical COVID-19: An important clue for uncontrolled immunothrombosis/thromboinflammation

중요한 COVID-19에서 조절되지 않는 miRNA 네트워크: 통제되지 않는 면역혈전증/혈전염증에 대한 중요한 단서

Review

Published on 2022-09-012022-09-11
Journal: International immunopharmacology
[Category] COVID19(2023년), SARS, 변종, 유전자 메커니즘, 치료기술,

[키워드] accompanied activated Activation adenine affecting anti-inflammatory factors Anticoagulant cause clinical complication Coagulation Coagulation system complement complement system Complication components conserved coronavirus disease Coronavirus disease 2019 COVID-19 Critical Cytokine storm Defensive mechanism deviation diffusion Effect expression expression level facilitate Factor function Genetic higher risk homeostasis hyperinflammation immune immunothrombosis incidence Interaction involved life-threatening mechanism microRNA MicroRNAs miRNA miRNAs miRNAs-based therapy. molecules Mortality NADPH nicotinamide nicotinamide adenine dinucleotide Nicotinamide adenine dinucleotide phosphate Non-coding RNAs nucleotide oxygen Pathogens Patient phosphate reactive oxygen species reactive oxygen specy reduction response restrict SARS-CoV-2 severe complications therapeutic approach therapy Thromboinflammation thrombotic underlie vicious cycle
[DOI] 10.1016/j.intimp.2022.109040 PMC 바로가기 [Article Type] Review

Potential of targeting host cell calcium dynamics to curtail SARS-CoV-2 infection and COVID-19 pathogenesis

Review article

Published on 2022-09-012022-10-05
Journal: Cell Calcium
[Category] SARS, 신약개발, 임상, 치료제,